Polymorphism of Haptoglobin in Patients with Premature Rupture of Membrane.
10.3349/ymj.2009.50.1.132
- Author:
Jin Kyung CHO
1
;
Yeun Hee KIM
;
In Yang PARK
;
Jong Chul SHIN
;
Mi Kyung OH
;
Seon Joo PARK
;
Nam Hoon KIM
;
In Sook KIM
Author Information
1. Department of Natural Sciences, College of Medicine, The Catholic University of Korea, Seoul, Korea. ikim@catholic.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Haptoglobin;
genetic polymorphism;
phenotype;
premature rupture of membrane (pregnancy)
- MeSH:
Adult;
Asian Continental Ancestry Group/*statistics & numerical data;
Female;
Fetal Membranes, Premature Rupture/*ethnology/*genetics;
Gene Frequency;
Genetic Predisposition to Disease/ethnology;
Haptoglobins/*genetics;
Humans;
Incidence;
Infant, Newborn;
Korea/epidemiology;
Phenotype;
*Polymorphism, Genetic;
Pregnancy
- From:Yonsei Medical Journal
2009;50(1):132-136
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To investigate whether allelic polymorphism of haptoglobin (Hp) is associated with premature rupture of membrane (PROM), the Hp phenotypes of pregnant women with PROM were analyzed. PATIENTS AND METHODS: The Hp phenotypes of 221 pregnant Korean women (187 control and 34 PROM patients) were determined by benzidine/hydrogen peroxide staining, following native polyacrylamide gel electrophoresis of hemoglobin-mixed sera. The Hp allele frequencies were calculated from the data of Hp phenotypes, and overall association with PROM was evaluated using Pearson Chi-Square test. RESULTS: The polymorphic distribution of the patients cohort who underwent a normal delivery (control group) was similar to that of healthy Koreans. In contrast, however, patients with PROM showed significantly higher occurrence of the Hp 1-1 phenotype than control group (23.5% vs 8.0%). Hp 2-2 phenotype was lower in PROM cohort (38.2%) than in the control group (48.7%). The Hp1 allele frequency in PROM group was significantly higher than that in the control group (0.426 vs 0.297, p = 0.034) with odds ratio of 1.762 (95% CI: 1.038 - 2.991). CONCLUSION: These findings suggest that pregnant Korean women who possess Hp1 allele (expressed as Hp 1-1 phenotype) have higher incidence of PROM than women with Hp2 allele (expressed as Hp 2-2 phenotype). This is the first study that evaluated the significance of Hp polymorphism with respect to the development of PROM.
