Protective effects of hypercapnia on acute lung injury and it's mechanisms
- VernacularTitle:高碳酸血症对急性肺损伤拮抗作用的研究及其机制的探讨
- Author:
Lili YANG
;
Zhi LIU
;
Xinping JI
;
Gang LIU
;
Fulan GUAN
- Publication Type:Journal Article
- Keywords:
Hypercapnia;
Lung diseases;
Respiratory distress syndrome, adult;
Carbon dioxide
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate whether hypercapnia is protective against acute lung injury (ALI) in a rabbit model, and study it's potential mechanisms. METHODS: Twenty-two healthy New Zealand white rabbits were involved in this study, and randomly allocated to control group (group C), normocapnic group (group N) and hypercapnic group (group H). Oleic acid (0 1 mL/kg) was injected intravenously to establish ALI model. Lung mechanics, hemodynamics, blood-gas analysis, the content of malondialdehyde (MDA) and superoxide dismutase (SOD) activity in lung tissue were measured. Apoptosis was analyzed after 3h mechanical ventilation. RESULTS: (1) Peak airway pressure in group H was significantly lower than that in group N (P
