Effect of propolis on the expression of CD54 and activation of NF-?B p65 of lung tissue in acute lung injury rats
- VernacularTitle:蜂胶对急性肺损伤大鼠肺组织中NF-?B活性及CD54表达的影响
- Author:
Fuliang HU
;
Minli CHEN
;
Yinghua LI
;
Wei ZHU
;
Huazhong YING
- Publication Type:Journal Article
- Keywords:
Propolis;
Repiratory distress syndrome, adult;
Intercellular adhesion molecule-1;
CD54;
NF-kappa B
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effect of propolis on the expression of CD54 and activation of NF-?B p65 in lung tissue of acute lung injury (ALI) rats. METHODS: 40 male Wistar rats were divided into 5 groups: normal control, model control, dectancyl group, water soluble derivative of propolis (WSP) group and ethanol extracted propolis (EEP) group. ALI animal model was performed by oleic acid and LPS twice attack. The pathologic slice was observed with light microscope and the NF-?B p65 activity and CD54 expression were tested by immunohistochemistry (SABC and SP). RESULTS: Both EEP and WSP antagonized the lung edema, decreased the inflammation and inhibited the expression of CD54 and activation of NF-?B p65. CONCLUSION: The increase in the expression of CD54 and the activation of NF-?B p65 in the lung tissues of ALI were involved in the formation of ALI. Propolis ameliorated the lung damage, which maybe related to the inhibition of CD54 expression and NF-?B p65 activation.
