Effects of thymosin ?_1 on the development and maturation of thymocytes
- VernacularTitle:?_1胸腺肽对胸腺细胞发育和成熟的影响
- Author:
Ting ZHANG
;
Shuqiu WANG
;
Yunhui SUN
;
Jianhua ZHANG
;
Fengyou XING
- Publication Type:Journal Article
- Keywords:
Thymosin;
Thymocytes;
Development
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of Thymosin ? 1 on the development and matutation of thymocytes. METHODS: The proportion of CD4+CD8+ thymocytes and the expression of smoothened (Smo) of the hedgehog (Hh)-signaling in CD4-CD8-thymocytes were examined to observe the effect of thymosin ? 1 on thymocyte development and matutation. RESULTS: Flowcytometric analysis showed that thymosin ? 1 showed activity at a low dose of 30 ?g/kg, and 30 ?g/kg thymosin ? 1 accelerated the replenishment and maturation of thymocytes according to the expression of Smo of the Hh-signaling in CD4-CD8-thymocytes, the potent negative regulator of proliferative responses. CONCLUSION: Thymosin ? 1 can accelerate thymocyte development from CD4-CD8- to CD4+CD8+.
