Changes of portal hemodynamics in the development of experimental liver cirrhosis
- VernacularTitle:实验性肝硬化的病理变化形成过程中门静脉血流动力学的改变
- Author:
Changzhu LIU
;
Juling KUANG
;
Xiaomin FU
- Publication Type:Journal Article
- Keywords:
Rats;
Liver cirrhosis;
Hypertension, portal;
Hemodynamics
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To understand the formation of portal hypertension through the change of portal hemodynamics on experiment cirrhosis. METHODS: Carbon tetrachloride was subcutaneously injected in the rat. The changes of the portal hemodynamics in the pathological process of liver tissue were observed. RESULTS: The liver underwent degeneration, necrosis of hepatocytes, and the normal architecture of the liver lobules was replaced by pseudolobule, which consist of regenerative hepatocytes and fibrous septa. The diameter, the blood flow velocity and the blood flow quantity of portal were significantly higher than that in former group (P0 05). CONCLUSION: The changes in hemodynamics of the portal are in accordance with the changes in pathology of liver in the formation of liver cirrhosis.
