Role of focal adhesion kinase in vascular endothelial cell migration
- VernacularTitle:粘着斑激酶在血管内皮细胞迁移中的作用
- Author:
Guangbo LIANG
;
Huiming JING
- Publication Type:Journal Article
- Keywords:
Focal adhesion kinase;
Vascular endothelial cell;
Migration
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Focal adhesion kinase (FAK) is a non-receptor protein tyrosine kinase (PTK) that can localize indirectly to sites of clustering integrin family of heterodimeric receptors. As an important structure and signaling molecule in the adhesive complexes, which are large and stable referred as ‘focal adhesions’ or relatively small and transient within filopodia and lamellipodia named ‘focal complexes’, FAK is closely related with cell death, proliferation and migration. In this review, we discuss the function of FAK in the regulation of endothelial cell migration based on current data.
