A Study on the Correlation between the Polymorphism of GSTM1 and GSTT1 Genes and Susceptibility to the Development of COPD
- VernacularTitle:GSTM1和GSTT1基因多态性与COPD易感性的研究
- Author:
Zhiming MA
;
Zhenxiang ZHANG
;
Zemin HAN
- Publication Type:Journal Article
- Keywords:
GSTM1 and GSTT1 genotypes;
Homozygous deletion;
COPD;
Susceptibility;
Polymorphism
- From:
Journal of Chinese Physician
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between the polymorphism of GSTM1 and GSTT1 genes and the susceptibility to the development of COPD. Methods Polymerase chain reaction (PCR) was used to detect the GSTM1 and GSTT1 genotypes in 91 cases of the patients with COPD (COPD group) and 44 cases of the subjects without COPD (control group), and their susceptibility to the development of COPD were analyzed according to their gender, age and smoking history. Results There was significant difference in the frequency of GSTM1 0/0 genotype between the two groups of male persons with more than 40 years old (P
