A Study on the Relationship between TNF-? Level and Insulin Resistance in Patients with Type 2 Diabetes
- VernacularTitle:TNF-?值与2型糖尿病胰岛素抵抗的关系
- Author:
Wanbei GUO
;
Jianrui LI
;
Michael WHEELER
- Publication Type:Journal Article
- Keywords:
Tumor necrosis factor-?;
Type 2 diabetes;
Insulin resistance
- From:
Journal of Chinese Physician
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between serum level of tumor necrosis factor-?(TNF-?)and insulin resistance in patients with type 2 diabetes. Methods by using the homeostasis model assessment (Homa-R), 20 patients with insulin resistance(IR group) and 20 patients with non-insulin resistance(NIR group) were selected in this study, and 20 age and BMI-matched healthy subjects were also recruited as control group. Serum levels of insulin, TNF-?, lipids, apolipoprotein and glucose were measured after overnight fasting. Results The serum level of TNF-? was significantly higher in the patients of IR group than that in the patients of NIR group and the subjects of control group(P
