Electroencephalographic Study on Effects of Topiramate on Patients with Refractory Partial Epilepsy
- VernacularTitle:托吡酯添加治疗难治性部分性癫痫的脑电图研究
- Author:
Guoliang LI
;
Ning ZHENG
;
Ging LI
;
Al ET
- Publication Type:Journal Article
- Keywords:
Epilepsy;
Fructose;
Anticonvulsivant;
Electroencephalogram
- From:
Journal of Chinese Physician
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of topiramate(TPM) on the electroencephalogram(EEG) epileptiform wave and background activity in patients with refractory partial epilepsy. Methods Fifty-four patients with partial epilepsy resistant to conventional AED treatment were enrolled in the study. All patiants underwent rountine EEG detection during baseline days and the drug titration and maintenance phases after TPM treatment. Results After receiveing TPM, 10 patients( 19%) became seizure free and the overall seizure frequency was reduced by ≥50% in 35 patients(65%). Mild or moderate side effects were observed in 26 patients (48%).Quantitative analysis of the interictal EEG paroxysms revealed that the interictal epileptiform discharges(IED) vanished or decreased obviously in those patients who displayed a significant reduction (≥50%) in seizure occurrence, but the IED increased significantly in 9 3% of the patients. EEG background activity abnormalities(38 9%) induced by TPM consisted of increased delta and theta activities and decreased alpha activity. Conclusion The results indicated TPM being an effective drug used as adjuvant therapy in refractory partial seizure. TPM dose should increase gradually under EEG monitoring to detect side effects related to the central nervous system early.The EEG changes associated with the side effects mainly were increased activity in the slower frequency rhythm.
