Study on Relationship between nm23 Gene and the Inhibition Effect of Arsenic Trioxide on Human Gastric Carcinoma
- VernacularTitle:nm23基因与三氧化二砷抗胃癌作用关系的研究
- Author:
Ru ZHANG
- Publication Type:Journal Article
- Keywords:
Arsenic trioxide;
nm23;
Immunohistochemistry
- From:
Journal of Chinese Physician
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the inhibiting effect of arsenic trioxide(As 2O 3) on tumor and nm23 gene expression. Methods The human gastric carcinoma cell line was treated with As 2O 3. Then immunohistochemistry was used to detect nm23 protein expression. Results As 2O 3 up-regulated the expression of nm23 in gastric carcinoma cells. Conclusion The inhibiting effect of As 2O 3 on gastric carcinoma cells may be related with upregulation of nm23 expression, which decreases the gastric cancer cells metastatic ability.
