Expression of COX-2 in Bladder Transitional Cell Carcinoma and its Association with Tumor Cell Proliferation and Apoptosis
- VernacularTitle:膀胱移行细胞癌COX-2表达及其与肿瘤细胞增殖和凋亡的关系
- Author:
Qinzhang WANG
;
Rong WANG
;
Guofu DING
- Publication Type:Journal Article
- Keywords:
Bladder neoplasms;
Cyclooxygenase-2;
Ki67;
Apoptosis
- From:
Journal of Chinese Physician
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression level of cyclooxygenase-2 (COX-2) and its effects on cell proliferation and apoptosis in bladder cancer. Methods The immunohistochemical method was used to determine the expression of COX-2 and Ki67 in 54 cases of bladder cancer, 29 cases of adjacent tumor tissue and 10 cases of normal bladder specimen respectively, and the apoptotic levels of the obove three tissues were assessed by counting the number of the cells labeled by TUNEL method. Results The positive rate of COX-2, the mean labelling index of Ki67 and the cellular apoptosis index in the cancer tissues were significantly higher than those in adjacent tumor tissues and normal bladder specimens(P
