Effect of Fluvastatin on Endothelium-Dependent Dilation Function
- VernacularTitle:氟伐他汀对血管内皮依赖性舒张功能的影响
- Author:
Yan ZHOU
;
Guinan LIU
;
Yanjun LIU
- Publication Type:Journal Article
- Keywords:
Fluvastatin;
Endothelium,vascular;
Vasodilation;
Nitric oxide;
Nitric oxide synthase
- From:
Chinese Circulation Journal
2004;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess effect of fluvastatin on vascular endothelium-dependent diastolic function of hypercholesterolemia patients. Methods:Thirty five patients with hypercholesterolemia were treated with fluvastatin (40 mg/d,po) for 8 weeks. 25 healthy adults were as control group.The baseline of brachial angiobore and the changes of it at response to nitroglycerin and reactive hyperemia were measured by Dopple ultrasound before and after treatment in hypercholesterolemia patients. Blood lipids,blood concentrations of NO and NOS were also measured before and after treatment. Results:①In patients with primary hypercholesterolemia the vascular endothelium-dependent dilation function (EDD)was much reduced as compared with the control, so as for blood concentrations of NO and NOS. ② Serum total cholesterol,low density lipoprotein cholesterol and triglycerides were significantly lowered by 8-week treatment of fluvastatin(p
