Comparison of Forcep-biopsy and Cryo-biopsy by a Flexible Bronchoscopy.
10.4046/trd.2009.66.2.110
- Author:
Jae Hyun KIM
1
;
Jung Min CHOI
;
Sung Eun SONG
;
Eun Mi LEE
;
Song Ju LEE
;
Chul Ho OAK
;
Tae Won JANG
;
Man Hong JUNG
;
Hee Kyung JANG
Author Information
1. Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea. oaks70@hanmail.net
- Publication Type:Original Article
- Keywords:
Forcep-biopsy;
Cryo-biopsy;
Endobronchial carcinoma
- MeSH:
Bronchoscopes;
Bronchoscopy;
Extreme Cold;
Hemorrhage;
Humans;
Prospective Studies;
Vascular Endothelial Growth Factor A
- From:Tuberculosis and Respiratory Diseases
2009;66(2):110-115
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: A forceps-biopsy is performed to acquire tissue from patients with an endobronchial carcinoma using a flexible bronchoscope. Recently, a cryo-biopsy has also been used to acquire tissue samples. Cryo-biopsy is the diagnostic application of extreme cold for the local destruction of abnormal living tissue. This technique is safe, with no radiation danger, no risk of electrical accidents, and a little risk of bleeding. This study compared a forceps-biopsy with a cryo-biopsy using a flexible bronchoscope, and examined the chemosensitivity and level of VEGF (vascular endothelial growth factor) in the specimens obtained from the cryo-biopsy. METHODS: We present a prospective study of 30 consecutive patients who underwent a forceps-biopsy between January 2007 and October 2007 with a mean age of 62.1 years and a male:female ratio of 5 : 1. A flexible bronchoscope was inserted to the area of the abnormal lesions, and a cryo-probe was then applied through the working channel of the flexible bronchoscope. A temperature of approximately -80 was delivered to the tumor site for 8 seconds. The cryo-biopsy was performed after destroying the tumor mass. RESULTS: The mean size of the tissue from the forceps-biopsy and cryo-biopsy were 2.0+/-1.2 mm and 6.0+/-3.0 mm. A chemosensitivity test was performed on 5 specimens obtained using cryo-biopsy and the level of VEGF was examined in 2 specimens obtained from a cryo-biopsy. There were no side effects in either group. CONCLUSION: Cryo-biopsy using a flexible bronchoscope is a safe and effective technique for acquiring tissue samples.
