Protective effect of pentoxifylline on ischemia/reperfusion injury for the liver in rats
- VernacularTitle:己酮可可碱对肝脏缺血再灌注损伤保护作用的实验研究
- Author:
Gang WU
;
Yongfeng LIU
;
Donghua CHENG
;
Jian LIANG
;
Sanguang HE
- Publication Type:Journal Article
- Keywords:
LIVER ISCHEMIA;
REPERFUSION INJURY;
DISEASE MODELS,ANIMAL;
PTX
- From:
Chinese Journal of General Surgery
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the role of early release of tumor necrosis factor-?(TNF-?) and nuclear factor-?B(NF?B) activation on inflammatery mediators expression and neutrophil accumulation in the liver after ischemia/reperfusion . Methods The models of partial hepatic ischemia in Wistar rats were established. Rats received either Pentoxifylline (PTX) 50mg/kg(PTX group) or sterile saline (control group) via peritoneal injection at 1h before ischemia;Sham operation group was also established. Results Compared with control group,in PTX treatment group, the release of the TNF-?, the content of NF?B p65, expression of MIP-2 mRNAand ICAM-1 mRNA were significant decreased;the levels of MPO,AST,ALT, LDH,and W/D were also reduced significantly(all P
