Study on Decreasing Effects of Polydatin on Blood Viscosity in the Rat Model of Acute Blood Stasis
- VernacularTitle:虎杖苷降低急性血瘀模型大鼠血液粘度的研究
- Author:
Yu WANG
;
Xiaodong SUN
;
Bingxiang YUAN
;
Xiuling DENG
;
Xiaojiangpharmacology YU
- Publication Type:Journal Article
- Keywords:
Polydatin;
model of acute blood stasis;
plasma viscosity;
microcirculation;
hemorrheology
- From:
China Pharmacy
1991;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the decreasing effects of Polydatin on blood viscosity and microcirculation in the rat model of acute blood stasis.METHODS:The rat model of acute blood stasis was established with high dose of adrenaline sub?cutaneous injection in combination with ice-water socking.The parameters such as whole blood viscosity?bat low and high shear rates,hemotocrit,platelet adhesiveness testPAdT,fibrinogenFIB,plasma viscosity?petc.were used.RESULTS:The results showed that Polydatin reduced FIB,PAdT in rat model remarkably.It obviously caused a reduction of?p,which induced decrease of?b.The effect was more significant than any other factors in reducing blood viscosity and improving mi?crocirculation.CONCLUSION:Polydatin is helpful to reduce blood viscosity and improve microcirculation.The data provided would be useful for rational use of drug.
