Role of prostaglandins, nitric oxide and potassium channel in the blunting of hypoxic pulmonary vasoconstriction in the high altitude adaptive animal
- VernacularTitle:前列腺素、一氧化氮和钾通道在鼠兔缺氧肺血管反应钝化中的作用
- Author:
Tao WANG
;
Zhenxiang ZHANG
;
Shengyuan LIU
;
Tianyi WU
;
Bingyong SUN
;
Dixun WANG
- Publication Type:Journal Article
- Keywords:
Pika;
Nitric oxide;
Prostaglandins;
Potassium channels;
Anoxia;
Altitude;
Pulmonary artery
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the possible role of prostaglandin, NO and potassium channel in the adaptive blunting of hypoxic pulmonary vasoconstriction (HPV) in the high altitude animal (pika). METHODS: The effect of L-NAME, indomethacin and 4-AP on the response of isolated lung strips of pika and Wistar rats instead of pulmonary artery to acute hypoxia were studied. RESULTS: (1) After inhibition of prostaglandins by indomethacin, the percentage increase in hypoxic constriction in lung tissue strip of pikas was greater than that in Wistar rats[(64.7?50.9)% vs (19.7?14.1)%], P
