Effects of rhBMP-2/collagen composite on the remodeling of rat interparietal suture after rapid expansion
- VernacularTitle:rhBMP-2/胶原膜复合物对扩张力作用下大鼠顶骨矢状缝改建的影响
- Author:
Renfa LAI
;
Zhiying ZHOU
;
Weidong KONG
;
Hao XU
;
Tao YE
- Publication Type:Journal Article
- Keywords:
Bone morphogenetic proteins;
Bone regeneration;
Rats
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: The purpose of this study was to investigate the effects of rhBMP-2/collagen composite on bone regeneration during expansion of the interparietal suture in the rats. METHODS: 32 10-week old SD rats were divided into groups consisting of 8 rats each. They were comprised of normal control group, expansion control group and the treatment group, the two treatment groups were covered with atelo-typeⅠcollagen and rhBMP-2/collagen composite on the suture before subjected to the expansion force. The bone regeneration in the interparietal suture was estimated by histological method, the osteocalcin content was measured by radioimmonoassay and the calcium content was determined by atomic absorption spectrophotometer. RESULTS: The bone regeneration was more active in the suture after giving an expanding force than in the suture without any intervention. Even bone bridge was formed in the rhBMP-2/collagen composite group. Both the osteocalcin content and calcium content were much higher in the rhBMP-2/collagen composite group than in other three groups (P
