Changes of cortisol content in plasma and hippocampus after focal cerebral ischemia-reperfusion in rats
- VernacularTitle:局灶性脑缺血再灌注后大鼠血浆和海马皮质醇含量变化
- Author:
Cuibai WEI
;
Jinzhou TIAN
;
Yipeng TANG
;
Junxiang YIN
- Publication Type:Journal Article
- Keywords:
Hydrocortisone;
Hippocampus;
Brain ischemia
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the relationship between glucocorticoid (Gc) and injury of hippocampus neurons and the effect of Gc on dementia episode after cerebral ischemia-reperfusion. METHODS: The rat model of middle cerebral artery occlusion (MACO) was established. Cortisol contents in hippocampus and plasma of the model rats were examined by means of the radioimmunoassay at 2 h, 6 h, 12 h, 24 h after reperfusion. RESULTS: The levels of cortisol content in model group were significantly higher than those in sham group and normal group both in hippocampus and plasma. The highest cortisol content was observed at 6 hours after reperfusion. HE staining showed that the impairment of hippocampus neurons was aggravated progressively with reperfusion interval elongating. CONCLUSION: The increased cortisol in hippocampus and plasma, after 2 h cerebral ischemia and 24 h reperfusion, could aggravate the injury of hippocampus neurons and lead to dementia post stroke.
