Expression of MIP-1? and RANTES gene and protein in the bronchus of murine asthma
- VernacularTitle:哮喘小鼠支气管MIP-1?、RANTES基因和蛋白的表达
- Author:
Weixi ZHANG
;
Changchong LI
;
Xiaoming CHENG
;
Xiaofang CHEN
;
Xiaohong CAI
;
Lin DONG
;
Rongxi WU
;
Zhengxia ZHANG
- Publication Type:Journal Article
- Keywords:
Epithelial cells;
Asthma;
Chemokines;
Mice
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the role of the gene and protein expression of MIP-1? and RANTES in the bronchus of murine asthma. METHODS: 20 male BALB/C mice were randomly divided into two groups: the control group (A 0 group) and asthma group (B 0 group). In the experiment, the mice model of asthma was established by the ovalbumin (OVA) challenge methods. The protein expression of MIP-1? and RANTES were detected by immunohistochemistry methods. The gene expressions of MIP-1? and RANTES were detected by in situ hybridization methods. RESULTS: Immunohistochemistry showed that the expressions of MIP-1? protein and RANTES protein around the bronchus of group B 0 were significantly higher than those of group A 0 (P
