Di-Ao-Xin-Xue-Kang's anti-peroxide protective effect against myocardial ischemia-reperfusion injury
- VernacularTitle:地奥心血康对心肌缺血再灌注损伤的抗脂质过氧化作用的研究
- Author:
Jian ZHANG
;
Xichun LIU
;
Dan ZHAO
;
Yang LI
;
Xuejian ZHAO
;
Jie XU
;
Ruiyun ZHAN
;
Guizhen LIU
- Publication Type:Journal Article
- Keywords:
Myocardial reperfusion injury;
Lipid peroxides;
Di-ao-xin-xue-kang;
Hydroxyl radical
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the protective effect and mechanisms of di-ao-xin-xue-kang (DK) on myocardial ischemia-reperfusion. METHODS: Models of myocardial ischemia-reperfusion were constructed with sixteen mongrel dogs. The left ventricular pressure (LVSP), the marximal/minimum rate of LVSP (?dp/dt max) and the serum aspartate aminotransferase (AST), creatine kinase (CK), lactate dehydrogenase (LDH), malondialdehyde (MDA) were determined before and 90 minutes after occlusion, 120 and 240 minutes after reperfusion, and the MDA content in myocardial cell membrane prepared at 240 minutes after reperfusion was determined. The oxygen free radical was assayed with electron spin resonace spectroscopy (ESR) technique. RESULTS: ① LVSP and ?dp/dt max in the normal saline control (NS) group decreased with the time progress of occlusion-reperfusion, and it was the same in DK group, but the levels were significantly higher than that in NS group (P
