Study on the Expression of LMP1,CyclinD1 and Bcl-2 in Nasopharyngeal Carcinoma and Its Clinical Significance
- VernacularTitle:LMP1,cyclinD1和Bcl-2在鼻咽癌中的表达及其临床意义
- Author:
Hong ZHU
;
Liang ZENG
;
Zhihai XIE
- Publication Type:Journal Article
- Keywords:
Latent membrane protein1;
CyclinD1;
Bcl-2;
Nasopharyngeal carcinoma
- From:
Journal of Chinese Physician
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate LMP1,CyclinD1 and Bcl-2 expression in nasopharyngeal carcinoma(NPC) and its clinical significance,and analyze their relation. Methods LMP1,CyclinD1 and Bcl-2 expression was assayed respectively in 60 NPC tissues by immunohistochemical method. Results ⑴The positive expression rates of LMP1,CyclinD1 and Bcl-2 in NPC were 65%(39/60), 60%(36/60)and 65%(39/60) respetively; ⑵The mean survival period, the five-year survival rate and median survival period in the NPC patients with LMP1, cyclinD1 and Bcl-2 positive expression were significantly shorter than those in the NPC patients with LMP1, cyclinD1 and Bcl-2 negative expression (P
