Expression of Smad 3, 7 in Rats Renal Tissue after Unilateral Ureteral Obstruction and Effects of Shentong Capsule on Them
- VernacularTitle:单侧输尿管梗阻大鼠Smad3,7的表达及肾通胶囊的影响
- Author:
Qingsong WAN
;
Mingzhu XIA
;
Jiacai HU
- Publication Type:Journal Article
- Keywords:
Renal interstitial fibrosis;
TGF-?1;
Smad 3;
Smad 7;
Shentong capsule
- From:
Journal of Chinese Physician
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of TGF-?1 and Smad 3, 7 in rats renal tissue after unilateral ureteral obstruction(UUO) and the effect of Shentong capsule on their expressions. Methods Sixteen rats underwent UUO and were devided into operation group and Shentong treatment group, additional 8 rats were shame operation group. The pathological change of renal tissues were examined by light microscopy 8 days after operation. The extent of renal fibrosis was determined by measuring the area of renal interstitial fibrosis. Immunhistochemistry was applied to detect the expression of TGF-?1 and Smad 3,7. Results In comparison with shame operation group, the expression of TGF-?1 and Smad 3 in operation group significantly increased, and the expression of Smad 7 significantly decreased(P
