A Study on Relationship between iNOS and p53 Expression in Human Prostatic Carcinoma
- VernacularTitle:前列腺癌中iNOS与p53的关系及其作用的探讨
- Author:
Xianzheng JIANG
;
Zhi LONG
;
Jun YAN
- Publication Type:Journal Article
- Keywords:
Prostatic carcinoma;
p53;
Nitric oxide;
Inducible nitric oxide synthetase
- From:
Journal of Chinese Physician
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of inducible nitric oxide synthetase (iNOS) expression with the expression of mutation type p53 (mt p53) in prostatic carcinoma (PCa). Methods The expression levels of iNOS and mt p53 were in 28 PCa specimens and 10 cases of benign prostatic hyperplasia (BPH) were detected by immunohistochemical method. Results The expression levels of both iNOS and mt p53 in PCa were higher than those in BPH. The expression of iNOS was related to the expression of p53 protein. Conclusion iNOS and mt p53 may play a role in the pathogenesis of PCa.
