A Study on the Relationship between TGF-?1 Expression and the Cellular Proliferation Activity in Gastric Carcinoma
- VernacularTitle:胃癌TGF-?1蛋白表达及与癌细胞增殖活性的关系研究
- Author:
Hua TANG
;
Caiquan ZHANG
;
Zheng XIANG
- Publication Type:Journal Article
- Keywords:
TGF-?1;
Gastric carcinoma;
Immunohistochemistry;
Ki-67
- From:
Journal of Chinese Physician
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of transforming growth factor-?1(TFG-?1) and its correlation with the cellular proliferation activity in human gastric carcinoma (GC). Methods The expression of TGF-?1 and Ki-67 in 50 GC tissues and 10 normal gastric mucosal tissues was examined by immunohistochemistry. Results Compared with the normal gastric mucosal tissues, the expression of TGF-?1 and Ki-67 in GC was significantly higher. TGF-?1 expression was associated with histological differentiation,lymphatic metastasis and invasion depth of GC. And Ki-67 expression was related with lymphatic metastasis and invasion depth of GC too. Furthermore, a significant correlation between TGF-?1 and Ki-67 expressions in GC was found as well. Conclusion Gastric carcinomas with expression of TGF-?1 had high cellular proliferation activity. TGF-?1 could not inhibit cellular proliferation in GC. TGF-?1 stimulated GC cells invasion and metastasis. The overexpression of TGF-?1 and Ki-67 can serve as a reference marker to evaluate GC biological behavior.
