Selection of the Formula of the 0.5% Liposome Podophyllotoxin Chitosan Film
- VernacularTitle:0.5%脂质体鬼臼毒素壳聚糖膜剂制备配方的优选
- Author:
Xiaoliang ZHU
;
Kang ZENG
;
Sanquan ZHANG
- Publication Type:Journal Article
- Keywords:
Orthogonal design;
Liposome podophyllotoxin;
Chitosan;
Film
- From:
Journal of Chinese Physician
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the best formula of the 0 5% liposome podophyllotoxin chitosan film. Methods Chitosan,acetic acid and gelatin were selected as three factors to prepare film, each factor including three levels, and 0 5% liposome podophyllotoxin served as blank factor. The films of different formula were prepared according to orthogonal design. The evaluation was made on the basis of the characteristics of conglutination and dissolution, then the best formula was determined finally. Results The results showed that the conglutination and dissolution of the film which was made of 2% chitosan, 1%acetic acid, 2% gelatin and 0 5% liposome podophyllotoxin chitosan was the most perfect. Conclusion The film designed according to orthogonal experiment was coincidenced with the requirements in aspect of conglutination and dissolution, and its appearance was perfect.
