The Effect of Anxiety and Depression on Cell Adhesion Molecules and Fibrolytic Activity in Cardiac-pacing Patients
- VernacularTitle:焦虑抑郁对心脏起搏患者细胞黏附分子和纤溶活性的影响
- Author:
Haitao YANG
;
Shushan QI
;
Shenghua ZHOU
- Publication Type:Journal Article
- Keywords:
Anxiety;
Depression;
Cardiac-Pacing;
Cell adhesion molecules;
Fibrolytic activity
- From:
Journal of Chinese Physician
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of anxiety and depression on cell adhesion molecules and fibrolytic activity in cardiac-pacing patients. Methods The levels of plasma P-selectin, E-selectin, sICAM-1, vWF and PAI-1 were measured in 39 cardiac-pacing patients with anxiety or depression as rersearch group, 32 cases cardiac-pacing patients without any psychological problems as observation control group and 20 healthy subjects as normal control group. Result The levels of plasma P-selectin, E-selectin, sICAM-1, vWF and PAI-1 in cardiac-pacing patients were significantly higher than those in normal control group, and their plasma levels in the patients with anxiety or depression were significantly higher than those in the patients without psychological problems. Conclusion There were significantly elevated cell adhesion molecules level and decreased fibrolytic activity in cardiac-pacing patients. The anxety and depression status could aggregate this condition.
