Thrombolytic drug infusion via carotid artery treating experimental central retinal artery occlusion
- VernacularTitle:经颈内动脉灌注溶栓药治疗实验性视网膜中央动脉阻塞
- Author:
Yong YAO
;
Jiping CAI
;
Xiaowen SHEN
- Publication Type:Journal Article
- Keywords:
Retinal artery occlusion/drug therapy;
Photochemotherapy;
Urinary plasminogen activator/therapeutic;
Urinary plasminogen activator/administration & dosage;
Disease models, animal
- From:
Chinese Journal of Ocular Fundus Diseases
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic effects of thrombolytic drug infusion via carotid artery on experimental central retinal artery occlusion (CRAO), and observe the changes of fibrinolytic activity in the systemic circulation. Methods To dissolve the thrombi in 15 cats (30 eyes) with CRAO established by laser irradiating a branch of central retinal artery after intravenous injection of photochemical drugs, urokinase (UK) was directly infused via carotid artery in 5 cats (10 eyes) in group A or intravenously injected in 5 cats (10 eyes) in group B, and isotonic saline solution was intravenously injected in 5 cats (10 eyes) in group C respectively. The patency of the artery was evaluated by fundus fluorescein angiography. Moreover, the changes of fibrinolitic activity in the blood were observed by blood biochemical examination. Results Four hours after UK infusion, the complete repatency proportion was 80% (5 cats 8 eys) in group A, and 50% (4 cats 5 eyes) in group B. There was significant difference between the two groups. Besides, after the infusion, the indexes of coagulation, fibrinolysis, and anti-fibrinolysis in group A were better than those in group B and C (P
