The effect of somatostatin on expression of metalloproteinase-2 and tissue inhibitor matrix metalloproteinase-2 of implanted liver tumor after partial hepatectomy in nude mice
- VernacularTitle:生长抑素对裸鼠肝部分切除后肝癌组织基质金属蛋白酶-2及其抑制剂表达的影响
- Author:
Shiwen GONG
;
Jun MIN
;
Yajin CHEN
;
Qingjia OU
;
Tao CHEN
;
Zhonghua CHU
;
Shikun QIAN
;
Huizhen LIANG
- Publication Type:Journal Article
- Keywords:
Carcinoma, hepatocellular;
Somatostatin;
Hepatectomy;
Metalloproteinases;
Tissue inhibitor of metalloproteinase-2
- From:
Chinese Journal of General Surgery
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of somatostatin (SST) on the expression of metalloproteinase-2(MMP-2) and tissue inhibitor matrix metalloproteinase-2(TIMP-2) of implanted tumor in nude mice after partial hepatectomy.Method Nude mice were divided into group A(n=10) implanted by human hepatocellular carcinoma(HCC),group B(n=10, partial hepatectomy) and C(n=10,HCC implantation after liver resection). SST(250 ?g/kg,b.i.d) was given intraperitoneally in group C. Mice were sacrificed on 35th d, tumor was measured, the expression of MVD.MMP-2 and TIMP-2 was detected by immunochemical staining and quantitative image computer-analysis. Results In group B, the weight and volume and expression of MVD.MMP-2 of tumor tissue was markedly incressed than in group A(P
