A study on prolonging survival time of rats following 90% hepatectomy
- VernacularTitle:极限肝切除术后延长大鼠生存时间的研究
- Author:
Yilei MAO
;
Zhuo YU
;
Xinting SANG
;
Xin LU
;
Shouxian ZHONG
- Publication Type:Journal Article
- Keywords:
Hepatectomy;
Liver failure;
Mean survival time;
Atorvastatin;
AG490
- From:
Chinese Journal of General Surgery
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of atorvastatin and cytokine signaling inhibitor AG490 on the residual liver function and the survival time of 90% hepatectomy rats. Methods Rats were divided randomly into three groups after surgery: control group without treatment; Ato group administrated with atorvastatin (20 mg?kg -1?d -1) through NG tube one day before and three days after the surgery and AG490 group, intraperitoneally given AG490 (1 mg?kg -1?12h -1) beginning intraoperatively for 4 times. The health status and liver regeneration were observed and recorded. Results All rats in control group died within 24 hours. Both atorvastatin and AG490 significantly prolonged the survival time of rats after surgery (25.6 h & 30.6 h vs. 10.7 h,P
