Relationship betwent surum gastrin and the expression of gastrin in the cancer cell with the clinical behavior of patients with colorectal carcinoma cancer
- VernacularTitle:大肠癌患者血清及癌细胞胃泌素表达与其临床生物学行为的关系
- Author:
Chunping JIANG
;
Jianwei ZHU
;
Yuquan CHEN
;
Hongxun SHEN
;
Xiu YU
;
Ruixi CHEN
- Publication Type:Journal Article
- Keywords:
COLORETAL NEOPLASMS/pathol;
ADENOCARCINOMA/pathol;
GASTRIN/blood
- From:
Chinese Journal of General Surgery
1997;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the serum gastrin level, the expression of gastrin in colorectal carcinoma cells and observe the ultrastructure of gastrin secretory granule in colorectal carcinoma cells,in order to explore the relationship between gastrin and clinical behavior of colorectal carcinoma. Methods The serum gastrin and gastrin expression in colorectal carcinoma tissues of the 53 cases were examined by using radio-immunity analysis(RIA), immunohistochemistry and immunoelectron microscopic technique. Results Compared with control group,the preoperative level of serum gastrin in colorectal group was significantly increased, especially in well-differentiation adenocarcinoma . In the tissue of colorectal carcinoma, the gastrin expression rate was 56.6%. The expression rate of well-differentiated adenocaroinoma was higher than that in moderate and poor differentiation adenocarcinoma. Immunoelectron microscopy showed that the granules of protein A-gold (PAG) could be seen in different electro- density secretion granules in carcinoma cells, in intercellular space and on the surface of membrane of microvillus.Conclusions The level of serum gastrin and the expression of gastrin in cancer tissues in colorectal carcinoma patients are increased. The colorectal carcinoma cells may synthesize and secrete gastrin themselves, which may be correlated with clinical behavior of colorectal carcinoma.
