Detection of the expression of hypoxia-inducible factor 1 alpha in gastric mucosal disease by using tissue chip technique
- VernacularTitle:采用组织芯片技术检测胃黏膜病变中缺氧诱导因子-1?的表达
- Author:
Yong LIU
;
Mingzhi LU
;
Sheng YUAN
- Publication Type:Journal Article
- Keywords:
TISSUE CHIP;
STOMACH NEOPLASMS/pathol;
HYPOXIA-INDUCIBLE FACTOR
- From:
Chinese Journal of General Surgery
1997;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the significance of expression of hypoxia-inducible factor 1 alpha(HIF-1?) in gastric mucosal diseases. Methods Using tissue chip technique to creat tissue chip in 120 cases of vary gastric mucosal disease,and using S-P immunohistochemical methods to detect the expressions of HIF-1? in these tissue chips. Results The positive rates of HIF-1? was 28.3% in 120 tissue chips of gastric mucosal diseases. The positive rates of HIF-1? was 0, 10.0%, 40.0% and 63.3% in chronic superficial gastritis, chronic atrophic gastritis with intestinal metaplasia, chronic atrophic gastritis with dysplasia and intestinal type gastric cancer, respectively. The positive rates of HIF-1? of intestinal type gastric cancer and chronic atrophic gastritis with dysplasia were significantly higher than that in chronic superficial gastritis and chronic atrophic gastritis with intestinal metaplasia(P
