Study on the Dissolubility of Clarithromycin Slow - released Tablet
- VernacularTitle:克拉霉素缓释片释放度研究
- Author:
Chuang WU
- Publication Type:Journal Article
- Keywords:
clarithromycin;
slow-released tablet;
dissolubility
- From:
China Pharmacy
1991;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To study the dissolution rate of clarithromycin slow - released tablet in vitro. METHODS: The dissolubility of clarithromycin slow- released tablet was determined by UV - spectrophotometry .RESULTS: The Weibulls distribution function equation of self - prepared and imported clarithromycin slow - released tablets were lnln1/1-F(t)=1.5 291 lnt-3.7 539, (r = 0.9 842) and lnln1/1-F(t)=1.5 216 lnt-3.6 759,(r = 0.9 830) .respectively .The dissolution rates of self-prepared and imported slow - released tablets were comparable.CONCLUSION: The study indicates that the self - prepared slow - released tablet had satisfactory sustained release effect.The method established for assaying the dissolution rate was suitable for quality control of clarithromycin slow - released tablet.
