Mitochondrial membrane mechanism of rat heart injury induced by stress
- VernacularTitle:应激对大鼠心肌细胞线粒体膜通透性转换孔开放的影响及其分子基础的研究
- Author:
Huirong REN
;
Xinxing WANG
;
Jingbo GONG
;
Lingjia QIAN
;
Chongyu REN
- Publication Type:Journal Article
- Keywords:
Stress;
Heart injuries;
Mitochondria, heart;
Cell membrane permeability
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effects of stress on the opening of mitochondrial membrane permeability pore (PTP) in rat heart and explore the possible molecular mechanism underlying PTP opening. METHODS: Stress animal model was established. After strained for differnet time, all rats were killed and PTP opening degree were examined by spectrophotometer. Bcl-2, Bax expression levels were determined by Western blot. RESULTS: Stress induced PTP opning, Bcl-2 expression inhibition and Bax level elevation in myocardial mitochondria. CONCLUSION: PTP opening was the important mitochondrial mechanism of stress-induced heart injury. Decrease in Bcl-2 expression and increase of Bax level may be an important molecular basis for PTP opening.
