Changes of HO/CO pathway in renal hypertension of two-kidney one-clip hypertensive rats
- VernacularTitle:HO/CO通路在2K1C肾性高血压时的变化
- Author:
Dongwei PANG
;
Li HAN
;
Junchang LIU
;
Tiemin MA
;
Hai XU
- Publication Type:Journal Article
- Keywords:
Heme oxygenase (Decyclizing);
Carbon monoxide;
Hypertension, renal;
Lysine
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of heme oxygenase /carbon monoxide(HO/CO) system on the pathogenesis of hypertension and effect of Heme-L- Lysinate(HLL), Zine protoporphyrin-IX(ZnPPIX) on vascular tension in a two kidney one-clip model. METHODS: The changes in mean arterial pressure and heart rate as well as phenylephrine(PHE)-induced contraction in isolated aortic rings of HLL, ZnPPIX- treated rats were examined after intraperitoneal administration of HLL and carbon monoxide( CO). RESULTS: (1) Injection of exogenous CO resulted in a significant decrease in mean arterial pressure in Sham and 2K1C groups(P
