Changes of Ca~(2+) activated potassium channels and cellular proliferation in autogenous vein grafts
- VernacularTitle:自体移植兔静脉细胞增殖与钙激活钾通道的变化
- Author:
Jixian QIAN
;
Shengyun SONG
;
Baoan MA
;
Qingyu FAN
- Publication Type:Journal Article
- Keywords:
Transplantation, autologous;
Veins;
Vasospasm;
Ca 2+ activated potassium channel
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate changes of Ca 2+ activated potassium channels (K Ca) in autogenous vein grafts. METHODS: The contraction of venous ring was measured by means of perfusion in vitro. The intimal proliferation and proliferation of cultured smooth muscle cells (vascular smooth muscle cells, VSMCs) were observed by the means of computerised image analysis and MTT method, respectively. Furthermore, whole cell mode of patch clamp was used to record K Ca of VSMCs isolated from autogenous vein grafts. RESULTS: 1 week after transplantation there were no significant differences of contraction and intimal relative thickness between autogenous vein grafts and control. Contraction and intimal relative thickness of autogenous vein graft were significantly increased 2 weeks after transplantation (P
