Role of nitric oxide in proliferation and secretion effect of vascular endothelial cells induced by vascular endothelial growth factor
- VernacularTitle:一氧化氮在VEGF介导的内皮细胞增殖与分泌效应中的作用
- Author:
Qigong LIU
;
Yongdong LI
- Publication Type:Journal Article
- Keywords:
Endothelial growth factors;
Nitric oxide;
N-nitro-L-arginine methyl ester;
Endothelium,vascular;
Cells
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the role of nitric oxide in proliferation and secretion of vascular endothelial cells induced by vascular endothelial growth factorr (VEGF). METHODS: The in vitro cultured vascular endothelial cells of rabbit aorta were divided into control group, VEGF-treated group and VEGF+L-NAME treated group, the absorbance (A) value of vascular endothelial cells, endothelin-1(ET-1) and von Willebrand factor (vWF) in the supernatant were examined by WST-1 assay, radioimmunoassay and ELISA. RESULTS: The A value in VEGF and VEGF+L-NAME treated group were higher than that in control group (P
