Effect of indomethacin on tumor invasion in human laryngeal cancer Hep-2 cells
- VernacularTitle:吲哚美辛对人喉癌Hep-2细胞系侵袭力的影响
- Author:
Yu GAO
;
Jiqun WANG
;
Yanchun SHAN
- Publication Type:Journal Article
- Keywords:
Laryngeal neoplasms;
Indomethacin;
Neoplasm invasiveness;
Hep-2 cells
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To assess the effect of indomethacin on tumor invasion in a human laryngeal cancer Hep-2 cell line in vitro. METHODS: Hep-2 cells were exposed to indomethacin at different concentrations for 48 h. Then cell growth rate, the colony formation in soft agar medium and cell mobility were examined, and monolayer invasion assay was performed to assess cell invasion index. RESULTS: Preteatment with indomethacin inhibited the colony formation of Hep-2 cells and the cell mobility, and decreased the invasion index. CONCLUSION: Indomethacin can inhibit the invasion of Hep-2 cells.
