The role of adrenomedullin in diabetic nephropathy
- VernacularTitle:肾上腺髓质素在糖尿病肾病中的变化及作用
- Author:
Huimin LI
;
Heng MIAO
;
Xiuqin JIANG
- Publication Type:Journal Article
- Keywords:
Adrenomedullin;
Diabetic nephropathies;
Transforming growth factor beta;
Extracellular matrix
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the role of adrenomedullin (AM) in diabetic nephropathy. METHODS: We observed the changes in the expression and secretion of AM, TGF-? 1 in the cultured human mesangial cells under high glucose condition and the contents of the laminin and type IV collagen in the supernatants. The effect of intervention with AM was also observed. RESULTS: High glucose condition resulted in increase in the expression and secretion of AM TGF-? 1 laminin and type IV collagen. AM reversed the influence of high glucose on the cultured human mesangial cells. CONCLUSION: These results showed that high glucose condition is one of stimulating factors of AM and the renal protective action of AM may be associated with suppression of TGF-? 1 and reducing excessive accumulation of laminin and type IV collagen.
