Involvement of bFGF in the lung response to silica in a mouse model
- VernacularTitle:小鼠矽肺模型的建立及bFGF参与矽肺形成的研究
- Author:
Junjian XIANG
;
Jiayin SUN
;
Ning DENG
;
Hongyu YANG
- Publication Type:Journal Article
- Keywords:
Silicosis;
Fibroblast growth factor 2;
Fibroblasts;
Fibrosis
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the relationship between basic fibroblast growth factor (bFGF) and the development of silicosis in mice. METHODS: MTT test was utilized to examine the effects of bFGF-neutralizing antibody and the bronchoalveolar lavage fluid (BALF) of the mice exposed to silica on lung fibroblast cell growth. RESULTS: BALF from mice treated intrabronchially with silica promoted the growth of lung fibroblasts and anti-bFGF antibody inhibited the effect of BALF dramatically. CONCLUSION: These results indicates that bFGF secretion increases in lung in a mice silicosis model and participates in the development of silicosis.
