Therapeutic effects of losartan and astragalus membranaceus on diabetic nephropathy
- VernacularTitle:洛沙坦和黄芪治疗糖尿病性肾病的相关机制研究
- Author:
Lie FENG
;
Yi FENG
;
Xiaohua LU
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathies;
Losartan;
Astragalus membranaceus;
Nitric oxide;
Endothelin-1;
Transforming growth factor beta
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the protective effects of losartan and astragalus membranace on the kidney of diabetic rats, and to study their possible mechanisms. METHODS: The diabetic rats were induced by a single intraperitoneal injection of streptozotocin. At the end of 12th week,changes in urinary albumin excretion, urinary ? 2-MG excretion, Ccr,NO,ET-1 levels in blood, urinary and renal tissue were observed. Serum and urinary TGF-? 1 concentration,average volume of glomeruler,average thickness of glomerular basement membrane were also measured. RESULTS: In the treated diabetic rats, urinary albumin excretion, urinary ? 2-MG excretion, Ccr, urinary and renal tissue NO, urinary TGF-? 1, average volume of glomeruler, average thickness of glomerular basement membrane decreased obviously as compared with diabetic untreated rats. These effects were enhanced when losartan was combined with astragalus membranace. CONCLUSION: Losartan or astragalus membranace reversed the injury of renal structure and function in STZ-induced diabetic rats. The protective effects were enhanced when losartan was combined with astragalus membranace. The decrease in NO,ET,TGF-? 1 concentration in renal tissue may be one of mechanisms for this action.
