Extracellular roles of high-mobility-group B1
- VernacularTitle:高迁移率族蛋白B1的细胞核外作用
- Author:
Zhongtang WANG
;
Yongming YAO
;
Zhiyong SHENG
- Publication Type:Journal Article
- Keywords:
High mobility group proteins;
Sepsis;
Neurites;
Neoplasm metastasis;
Arteriosclerosis
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
High-mobility-group B1 (HMGB1), an abundant, highly conserved cellular protein, is widely known as a nuclear DNA-binding protein that stabilizes nucleosome formation, and facilitates gene transcription. Recent studies suggested that HMGB1 could be overexpressed and released from cellular nucleosome upon endotoxin and cytokine stimulation, or other stress challenge including burns, shock, as well as infection. Therefore, extracellular HMGB1 might be involved in the pathogenesis of sepsis and subsequent multiple organ dysfunction syndrome. Moreover, experimental data showed that extracellular HMGB1 might play vital roles in nerves development, tumor metastasis, atherosclerosis and restenosis after vascular damage.
