Effects of alterations in extracellular pH on the respiratory burst in neutrophils
- VernacularTitle:胞外pH对中性粒细胞呼吸爆发的影响
- Author:
Yanling LI
;
Chengyi LIU
;
Rui DUAN
;
Ya LI
- Publication Type:Journal Article
- Keywords:
Neutrophils;
Respiratory burst;
Extracellular space;
Hydrogenion concentration
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The respiratory burst of neutrophils is an important response in inflammation. The alterations in extracellular pH per se is not a sufficient trigger to the respiratory burst in neutrophils. While neutrophils in respose to conventional agonists, the respiratory burst in neutrophils is affected by the alterations in extracellular pH, and there is a direct relationship between intracellular and extracellular pH. O-? 2 production in neutrophils is decreased while H 2O 2 production is increased at acidic pH. O-? 2 release in neutrophils is enhanced at weak alkaline pH. Na+/H+ exchanger plays an important role in the regulation of the respiratory burst of neutrophils.
