Effect of Herpes Simplex Virus-2 Infection on the HLA Class II Antigen Expression of Human Monocytes
- VernacularTitle:单纯疱疹病毒2型对单核细胞表达HLA-II类抗原的影响
- Author:
Junhong AO
;
Liyi ZHOU
;
Xingping CHEN
- Publication Type:Journal Article
- Keywords:
HSV-2;
Monocyte;
HLA class Ⅱ antigen
- From:
Journal of Chinese Physician
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of HLA class II antigen of human monocytes in pathogenesis of herpes simplex virus-2 (HSV-2) infection. Methods Human monocytes were infected by HSV-2 (333 Strain). The cultured cells were collected at the first, third, 5th, and 7th days of post-infection. The expression of HLA class II antigen of the infected monocytes was measured by alkaline phosphotase anti-alkaline phosphotase method (APAAP). Results The expression of HLA class II antigen on the monocytes significantly decreased at the first day of post-infection,and then gradually increased and reached to the normal control level at the 7th day of post-infection. Conclusion HLA class Ⅱ antigen expression of monocytes was inhibited by HSV-2 infection at early stage, which may be one of means of virus escaping host immunity. The expression of HLA class Ⅱ antigen may play an important role in HSV-2 pathogenicity and immunity.
