The role of oncogene Stat3 in carcinogenesis and progression of human breast cancer
- VernacularTitle:癌基因Stat3在人乳腺癌发生发展中的作用
- Author:
Lin CHENG
;
Shan WANG
;
Yingjiang YE
;
Jiaqing ZHANG
;
Xinmin QIAO
;
Deqi YANG
;
Zhirong CUI
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Oncogene;
Apoptosis;
STAT3
- From:
Chinese Journal of General Surgery
1997;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aim of this study is to investigate STAT3 expression and the relationship between protein levels of STAT3 and clinicopathological parameters together with preoperative chemotherapy in human breast cancer. Methods Samples were obtained from 51 patients with breast carcinoma in which 7 patients had received preoperative chemotherapy. Western blot was used to measure the protein expression in tissue and SK-BR-3 cell line. MTT method was used to evaluate the proliferation. Cell-cycle and apoptosis were quantified by flow cytometry. Results STAT3 protein levels increased in breast cancer tissues compared with adjacent normal tissues(t=5.540,P
