Detection of Staphylococcus aureus-derived Exotoxins in Lesions of Childhood Atopic Dermatitis
- VernacularTitle:特应性皮炎患儿皮损局部金黄色葡萄球菌外毒素检测
- Author:
Huan XING
;
Yuejuan TONG
;
Lin MA
;
Yonghong YANG
- Publication Type:Journal Article
- Keywords:
Dermatitis, atopic;
Staphylococcus aureus;
Exotoxins;
Superantigens
- From:
Chinese Journal of Dermatology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To determine the prevalence of Staphylococcus aureus (S. Aureus) colonization and S. aureus-derived exotoxins in lesions of childhood atopic dermatitis (AD) and evaluate the role of S.aureus-derived exotoxins in the pathogenesis of childhood AD. Methods Specimens were taken from the skin lesions of 148 patients, non-lesional skin of 30 patients, and the skin of 250 controls for bacterial cultures. S. aureus-derived exotoxins were detected by reverse passive latex agglutination. Total IgE levels were determined with immunoradiometric assay. Results The prevalence of S. aureus colonization was significantly increased in both the lesional and non-lesional skin of patients with AD in comparison with the controls (P 0.05). However, patients with increased total IgE levels showed significantly high SCORAD indices (P
