Experiment Study of the New Method for Treating Injury Caused by Extravasation of Vincrisine
- VernacularTitle:长春新碱渗漏性损伤治疗方法的实验研究
- Author:
Lixin LI
;
Jincheng TAO
;
Bingying CHEN
;
Peili ZHU
- Publication Type:Journal Article
- Keywords:
vincrisine;
extravasation of drug;
anisodamine;
lidocaine
- From:
China Pharmacy
1991;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the effect of2%anisodamine plus1%lidocaine block therapy on injury caused by extravasation of vincrisine.METHODS:60animal models were established by injecting1%vincrisine5ml into ear vein with1ml purposely extravasating to subcutaneous tissue in rabbits.The rabbits were divided randomly into groupⅠ,groupⅡand control group.GroupⅠreceived2%anisodamine+1%lidocaine,groupⅡ2%anisodamine and control group normal saline.RESULTS:After2weeks treatment,the total effective and curative rate in three groups were90%and80%,63%and42%,15%and0%respectively.CONCLUSION:2%anisodamine plus1%lidocaine block therapy is superior to normal saline in treating extravasation injury of vincrisine.
