Protective Effects of Ginkgolides on Cerebral Ischemia in Experimental Rodents
- VernacularTitle:银杏内酯对实验性小动物脑缺血的保护作用
- Author:
Jun REN
;
Zhengping JIA
- Publication Type:Journal Article
- Keywords:
Ginkgolides;
mouse;
rat;
cerebral ischemia;
hemorrheology
- From:
China Pharmacy
1991;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the protective effects of Ginkgolides(GL)on cerebral ischemia in experimental rodents. METHODS:The models of decapitative mice and acute incomplete cerebral ischemic(AICI)rats were used.The gasp duration of decapitative mice and cerebral index,water content of brain,cerebral capillary permeability and hemorrheological parameters in rats were determined.RESULTS:Ginkgolides could prolong gasp duration of decapitative mice,increase the cerebral index and the water content of brain,inhibit capillary permeability,improve hemorrheological parameters and decrease blood viscosi?ty.CONCLUSION:Ginkgolides may antagonize the damage of cerebral ischemia.
