Study on Preparation and in Vitro Release of Doxofylline Sustained-release Capsules
- VernacularTitle:多索茶碱缓释胶囊的制备与体外释放度考察
- Author:
Yajun ZHANG
- Publication Type:Journal Article
- Keywords:
doxofylline;
sustained-release agent;
in vitro release of drug
- From:
China Pharmacy
1991;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare the doxofylline sustained-release capsules and evaluate it's in vitro release.METH_ ODS:The doxofylline sustained pellets were developed by rolling technique and coated by Eudragit RS100.UV-spectropho tometry was adopted to determine the dissolubility of doxofylline,which marked the release profiles of that cap?sules.RESULTS:The dissolubilities of the capsules were20%～40%,40%～80%and more than80%at2h,6h and10h re?spectively.CONCLUSION:The preparation procedure for doxofylline sustained-release capsules is feasible and repeatable.The capsules have obviously sustained property.
