Experiment of Percutaneous Absorption of Doxepin Cream in Human Body
- VernacularTitle:盐酸多塞平乳膏人体透皮吸收试验
- Author:
Xinjian YANG
;
Lei WANG
;
Ying LIANG
- Publication Type:Journal Article
- Keywords:
doxepin cream;
percutaneous absorption in human body;
HPLC;
blood drug concentration
- From:
China Pharmacy
1991;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare the percutaneous absorbency between imported and domestic5%doxepin cream.METHODS:In a cross design,8health male volunteers were enrolled in the study.Determination was performed by HPLC with chlorimipramine as internal standard.RESULTS:The same dose of domestic and imported doxepin cream was topically applied to the forearm skin of the volunteers for8consecutive days.The blood drug levels were very low in both groups without significant difference.CONCLUSION:The percutaneous absorbency of domestic5%doxepin cream can reach that of imported ones and the domestic cream is safe and effective.
