Significance of transforming growth factor ?_1 expression in the lung of neonatal premature rats exposed to hyperoxia
- VernacularTitle:转化生长因子?_1在新生未成熟大鼠高氧损伤肺组织中的表达及意义
- Author:
Guosheng LIU
;
Chuan NIE
;
Xianqiong LUO
- Publication Type:Journal Article
- Keywords:
Hyperoxia;
Lung diseases;
Transforming growth factor beta
- From:
Chinese Journal of Perinatal Medicine
1998;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study transforming growth factor ?_1 (TGF-?_1) expression in the lung of neonatal premature rats exposed to hyperoxia at different time. Methods 99 neonatal premature rats were assigned to hyperoxic group and air group randomly They were sacrificed at the postnatal 3 rd ,7 th and 14 th day,then their lungs were achieved for H.E staining and immunohistochemistry to measure the expression of TGF-?_1. The difference of TGF ?_1 expression were tested by rank-sum test. Results TGF-?_1 expression in hyperoxic group was always wider than that of air group at the corresponding period,and its expression in alveolar and bronchi epithelial cells as well as mesenchymal was stronger than that of control group(u respectively is: 49.0、14.0、63.0 at the 3 rd day;34.0、2.0、45.0 at 7 th day;and 32.0、13.5、33.0 at 14 th day (all P
